CMO Services in Microbial Fermentation

Wisconsin BioProducts provides end-to-end microbial (aerobic and anaerobic) fermentation—from process transfer and development through product recovery and final fill. Projects begin with a structured tech transfer and risk assessment, progress through engineering runs and pilot batches (250–1,500 L), and scale to commercial production supported by on-site QA/QC.

Fermentation

• Hosts: Experience in working with various E. coli, yeast, micro algae, fungal strains, other select microbes
• Operating Modes: Batch, fed-batch, Continuous (Draw and Fill)
• Controls: DO, pH, temperature, various antifoam strategies
• Scales: Bench to full production; total installed capacity ~165,000 L
• Deliverables: COA, batch record summary, retained samples, final deliverable product

Product Recovery (Downstream)

• Clarification/harvest, lysis where applicable
• Collection and Concentration of Cells via Centrifugation, Filtration (MF/UF), Homogenization, Chromatography, Sterilization
• Media/buffer preparation

Formulation & Packaging

• Primary and secondary packaging
• Sanitary Packaging
• Labeling with lot traceability
• On-site Cold Storage
• Direct tanker fill capability

QC & Release Testing

• In-process controls and final release criteria
• Documentation set provided (COA, batch summaries)